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CAS 70458-92-3 Pharmaceutical API Pefloxacin Powder Antibiotics

Basic Information
Place of Origin: China
Brand Name: HNB
Certification: ISO
Model Number: HNB-Pefloxacin
Minimum Order Quantity: 1KG
Price: Negotiable
Packaging Details: Aluminum foil bag
Delivery Time: Usually7-10days
Payment Terms: L/C, D/A, D/P, T/T, , MoneyGram
Supply Ability: 5000kg/Month
Detail Information
CAS: 70458-92-3 Mf: C17H20FN3O3
MW: 333.357 Specification: ≥98%
Appearance: White Powder Purity: 99%,99%min
Shelf Life: 2 Years Grade: Medical Grade,Phamaceutical Grade,Medicine & Tech,USP BP FCC EP
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API Pharmaceutical Pefloxacin Powder

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Pefloxacin Antibiotics Powder


Product Description

CAS 70458-92-3 Pharmaceutical API Pefloxacin powder antibiotics

CAS 70458-92-3 Pharmaceutical API Pefloxacin Powder Antibiotics 0

Product Name: Pefloxacin
Synonyms:

CIPROBAY

CAS: 70458-92-3
MF: C17H20FN3O3
MW: 333.357

The Introductction

1. Norfloxacin is the raw material and obtained by methylation.
 
2. Preparation from the intermediate boron chelate in Norfloxacin. The boron chelate, acetonitrile, n-methylpiperazine and triethylamine were mixed at room temperature and refluxed. Steam the solvent, add water, concentrated hydrochloric acid adjusted to Ph=3, then reflux. Add activated carbon to decolorize and filter. The filtrate was alkalized to Ph=11, decolorized with activated carbon, filtered, neutralized with 30% acetic acid to Ph=6.7-7.2, and refrigerated overnight. The white pefloxacin was obtained by filtration, washing and drying. The yield was 82% and the melting point was 270-272℃. Pefloxacin was dissolved in anhydrous ethanol, and mesulfonate was added at 60 ~ 70℃ for reaction. Cooled to 15℃, the filtered crystals were recrystallized with 10 times ethanol to obtain Pefloxacin mesylate with yield of 88.5%.
 
3. Boron chelates, N-methylpiperazine and triethylamine can also be reflux. Then alkaline hydrolysis, acidification to Ph=7.2, pefloxacin was obtained. Pefloxacin mesylate was obtained by recrystallization with 85% ethanol with yield of 79.4% and melting point of 284℃.
 

The Application & Function

 

Pefloxacin indication

 

Pefloxacin is third generation quinolones have broad spectrum antibacterial action, and their antibacterial spectrum and antibacterial activity are similar to that of piperfluoric acid. Inhibit or kill bacteria by interfering with DNA replication and protein synthesis. It has strong antibacterial action against Staphylococcus aureus, and has very strong antibacterial action against a variety of gram-negative bacteria and strains resistant to ampicillin and TMP cephalosporin. It is as effective against intestinal bacteria and the third generation cephalosporin, but has poor effect on anaerobic bacteria, tuberculosis bacillus and clostridium. Resistance is less likely to develop. It is used for sepsis, bacterial meningitis, respiratory tract, urethra, kidney, liver and bile, gynecological diseases, bone and joint infections.

 

This product belongs to fluoroquinolones, and its antibacterial action and mechanism in vitro are referred to Norfloxacin. This product is a new fluoroquinolone antibacterial agent with broad-spectrum activity against G- and G+ bacteria, including enterobacteriaceae, Pyomonas aeruginosa, Acinetobacter, Haemophilus, Neisseria and Staphylococcus (including methicillin-resistant strains). Its resistance to staphylococcus aureus was similar to that of vancomycin, but its resistance to pseudomonas aeroginosa was not as good as that of  and Cetazidine, and it was also effective for some polyvalent resistant strains and methicillin-resistant bacteria.

 

The COA

 

Item Specification Results
APPEARANCE WHITE CONFORMS
SOLUBILITY FREELY SOLUBLE IN CHLOROFORM;SOLUBLE IN WATER OR METHANOL; CONFORMS
PH 5.0-7.2 6.51
LOSS ON DRYING ≤4.5% 3.10%
RESIDUEON IGNITION ≤2.5% 0.281%
HEAVY METALS ≤20PPM <15PPM
TYRAMINE ≤0.35% 0.051%
RELATED COMPOSITIONS TYLOSIN A ≥80% A+B+C+D ≥95% 93% 98%
Conclusion Confirm with the standard  

Contact Details
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